Zidovudine sustained release matrix tablets were prepared by using two natural polymers and one semi-synthetic polymer. Three different ratios of polymers were selected for the fabrication of tablets, natural gums like (Hupugum, Sterculia gum) and semi-synthetic polymer like HPMCk100 at different ratios (5%, 10% and 15%) by direct compression method. The fabricated tablets were characterized for hardness, friability, drug content. In-vitro drug release studies were carried out in pH 1.2 buffer for 2 hrs and then in PH 6.8 phosphate buffer for 10 h. Dissolution studies were conducted for 12 hrs by the three polymers among them HPMCk100m showed more sustained nature with 96% efficiency compared to hupugum and sterculia gum. Order of release for all the formulations fitted zero order except F5, F7, F8 formulations followed first order kinetics. The mechanism of drug release from all the formulations followed anomalous mechanism.
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